Coordinated tumor immunity

Coordinated Control of Immunity to Muscle

Tumor Immunity

In a consideration of tumor immunity it appears desirable to discuss resistance to spontaneous tumors and to implanted tumor separately. Although results obtained with experimentally implanted tumors have contributed to the biology of tumors, these results can not be applied directly to spontaneous tumors and this is especially true with respect to immunity. It has long been recognized that imm...

Tumor-binding antibodies and tumor immunity

The remarkable capacity of the immune system to distinguish self from non-self makes it almost impossible to transmit cancers (or organs) from one individual to another in the absence of immunosuppressive drugs. Whereas rejection of donor cells bearing mismatched MHC alleles has been ascribed to direct activation of T cells by the altered MHC-peptide structures, the factors that initiate reject...

Radiation holidays stimulate tumor immunity

Radiotherapy is a standard treatment for cancer and is used since a long time as a stand-alone therapy or in combination with surgery and systemic therapies including immunotherapy. Its acts through induction of irreversible DNA damage to which tumor cells are more susceptible because of frequent mutations in DNA repair pathways. Fractioned radiotherapy, given as daily low doses during multiple...

Heteroclitic Immunization Induces Tumor Immunity

In tumor transplantation models in mice, cytotoxic T lymphocytes (CTLs) are typically the primary effector cells. CTLs recognize major histocompatibility complex (MHC) class I-associated peptides expressed by tumors, leading to tumor rejection. Peptides presented by cancer cells can originate from viral proteins, normal self-proteins regulated during differentiation, or altered proteins derived...